Acute toxicity and quality of life in dose-escalated proton reirradiation for locally recurrent rectal cancer: The prospective ReRad II trial

Acute toxicity and quality of life in dose-escalated proton reirradiation for locally recurrent rectal cancer: The prospective ReRad II trial

Background and purpose: Locally recurrent rectal cancer (LRRC) in pre-irradiated patients remains a clinical challenge. Intensity-Modulated Proton Therapy (IMPT) enables dose escalation with potential for improved tumour control without compromising dose to organs at risk (OAR). However, prospective...

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Main Authors: C.G Truelsen, H.S Rønde, J.F Kallehauge, J.E Szpejewska, R Bahij, L.V Diness, S.K Skriver, L.Ø Poulsen, B.M Havelund, B.G Pedersen, L.H Iversen, K.G Spindler, C.S Kronborg
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Locally recurrent rectal cancer
Dose-escalation
Reirradiation
Intensity-modulated proton therapy
Patient-reported outcomes
Toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630825000916
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http://www.sciencedirect.com/science/article/pii/S2405630825000916

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