Preclinical Study of Pharmacokinetic/Pharmacodynamic Analysis of Tebipenem Using Monte Carlo Simulation for Extended-Spectrum β-Lactamase-Producing Bacterial Urinary Tract Infections in Japanese Patients According to Renal Function

Preclinical Study of Pharmacokinetic/Pharmacodynamic Analysis of Tebipenem Using Monte Carlo Simulation for Extended-Spectrum β-Lactamase-Producing Bacterial Urinary Tract Infections in Japanese Patients According to Renal Function

Background/Objectives: The increasing prevalence of urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing organisms poses a significant clinical challenge worldwide due to limited oral treatment options. Tebipenem (TBPM), an oral carbapenem antibiotic, is currently...

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Main Authors: Fumiya Ebihara, Takumi Maruyama, Hidefumi Kasai, Mitsuru Shiokawa, Nobuaki Matsunaga, Yukihiro Hamada
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antibiotics
Subjects:
tebipenem
extended-spectrum β-lactamase
urinary tract infection
pharmacokinetics/pharmacodynamics
renal function
Monte Carlo simulation
Online Access:https://www.mdpi.com/2079-6382/14/7/648
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