Multifactorial resistance mechanisms associated with resistance to ceftazidime-avibactam in clinical Pseudomonas aeruginosa isolates from Switzerland

Multifactorial resistance mechanisms associated with resistance to ceftazidime-avibactam in clinical Pseudomonas aeruginosa isolates from Switzerland

BackgroundIncreasing reports of multidrug resistance (MDR) in clinical Pseudomonas aeruginosa have led to a necessity for new antimicrobials. Ceftazidime-avibactam (CZA) is indicated for use against MDR P. aeruginosa across a broad range of infection types and particularly those that are carbapenem...

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Bibliographic Details
Main Authors: Baharak Babouee Flury, Anja Bösch, Valentin Gisler, Adrian Egli, Salome N. Seiffert, Oliver Nolte, Jacqueline Findlay
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Pseudomonas aeruginosa
ceftazidime-avibactam (CZA)
molecular resistance mechanisms
imipenem
whole genome sequencing (WGS)
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1098944/full
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https://www.frontiersin.org/articles/10.3389/fcimb.2023.1098944/full

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