Identification of a stromal immunosuppressive barrier orchestrated by SPP1+/C1QC+ macrophages and CD8+ exhausted T cells driving gastric cancer immunotherapy resistance

Identification of a stromal immunosuppressive barrier orchestrated by SPP1+/C1QC+ macrophages and CD8+ exhausted T cells driving gastric cancer immunotherapy resistance

PurposeThe heterogeneity of immune cells is a critical manifestation of gastric cancer (GC) heterogeneity and significantly contributes to immune therapy resistance. Although previous studies have focused on the roles of specific myeloid cells and exhausted CD8+ T cells in immune resistance, the imm...

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Bibliographic Details
Main Authors: Guichuang Ma, Xiaohan Liu, Qinrui Jiang, Shaowei Li, Qijing Wu, Bishan Liang, Fei Sun, Chunhui Gu, Wangjun Liao, Zhihua Zhang, Min Shi, Qiong Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
gastric cancer
immune microenvironment
immunotherapy resistance
macrophages
exhausted CD8 + T cells
cellular interaction network
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618591/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618591/full

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