Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children
The urine levels of cortisol and 6-β-hydroxycortisol in 30 healthy children were determined with high performance liquid chromatography. The activity of cytochrome P450 isoenzyme CYP3A4 was estimated by the ratio of 6-β-hydroxycortisol and cortisol. Differences in the CYP3A4 activity depended on the...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/418 |
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| author | B. I. Kantemirova A. KH. Chernysheva A. K. Starodubtsev D. A. Sychev |
| author_facet | B. I. Kantemirova A. KH. Chernysheva A. K. Starodubtsev D. A. Sychev |
| author_sort | B. I. Kantemirova |
| collection | DOAJ |
| description | The urine levels of cortisol and 6-β-hydroxycortisol in 30 healthy children were determined with high performance liquid chromatography. The activity of cytochrome P450 isoenzyme CYP3A4 was estimated by the ratio of 6-β-hydroxycortisol and cortisol. Differences in the CYP3A4 activity depended on the age sex. At the age of 4 to 9 years the value of the ratio was 9.21+0.67 which in fact was statistically higher than that in the children at the age of 0 to 3 years (p |
| format | Article |
| id | doaj-art-9a21400d0d3845d48e1a34fc7324f3a5 |
| institution | Matheson Library |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-9a21400d0d3845d48e1a34fc7324f3a52025-08-03T13:04:46ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01571-22325417Study on Phenotypical Activity of Isoenzyme CYP3A4 in ChildrenB. I. Kantemirova0A. KH. Chernysheva1A. K. Starodubtsev2D. A. Sychev3Astrakhan State Medical AcademyAstrakhan State Medical AcademyI. M. Sechenov 1st Moscow State Medical UniversityI. M. Sechenov 1st Moscow State Medical UniversityThe urine levels of cortisol and 6-β-hydroxycortisol in 30 healthy children were determined with high performance liquid chromatography. The activity of cytochrome P450 isoenzyme CYP3A4 was estimated by the ratio of 6-β-hydroxycortisol and cortisol. Differences in the CYP3A4 activity depended on the age sex. At the age of 4 to 9 years the value of the ratio was 9.21+0.67 which in fact was statistically higher than that in the children at the age of 0 to 3 years (phttps://www.antibiotics-chemotherapy.ru/jour/article/view/418xenobioticsbiotransformationcytochrome р450isoenzyme cyp3a4 |
| spellingShingle | B. I. Kantemirova A. KH. Chernysheva A. K. Starodubtsev D. A. Sychev Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children Антибиотики и Химиотерапия xenobiotics biotransformation cytochrome р450 isoenzyme cyp3a4 |
| title | Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children |
| title_full | Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children |
| title_fullStr | Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children |
| title_full_unstemmed | Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children |
| title_short | Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children |
| title_sort | study on phenotypical activity of isoenzyme cyp3a4 in children |
| topic | xenobiotics biotransformation cytochrome р450 isoenzyme cyp3a4 |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/418 |
| work_keys_str_mv | AT bikantemirova studyonphenotypicalactivityofisoenzymecyp3a4inchildren AT akhchernysheva studyonphenotypicalactivityofisoenzymecyp3a4inchildren AT akstarodubtsev studyonphenotypicalactivityofisoenzymecyp3a4inchildren AT dasychev studyonphenotypicalactivityofisoenzymecyp3a4inchildren |