STS2 deficiency revives CD8+T cells from exhaustion and augments checkpoint blockade efficacy in cancer immunotherapy

Background T-cell exhaustion is a major barrier to effective antitumor immunity and limits the efficacy of cancer immunotherapies. This study investigates the role of suppressor of T-cell signaling 2 (STS2, also known as UBASH3A) in regulating CD8+ T-cell exhaustion within the tumor microenvironment...

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Príomhchruthaitheoirí: Chunxiao Li, Fei Ma, Ying Zhang, Ting Wang, Hongnan Mo, Ning Zhong, Dongkui Xu, Fangzhou Sun, Yantong Zhou, Jianbin Guo, Zhenguo Zhao, Xiaoqi Yang, Haili Qian
Formáid: Alt
Teanga:Béarla
Foilsithe / Cruthaithe: BMJ Publishing Group 2025-06-01
Sraith:Journal for ImmunoTherapy of Cancer
Rochtain ar líne:https://jitc.bmj.com/content/13/6/e010735.full
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