Chelerythrine Chloride Alleviated Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Glycolytic Pathway Through Targeting Glyceraldehyde-3-Phosphate Dehydrogenase

Chelerythrine Chloride Alleviated Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting Glycolytic Pathway Through Targeting Glyceraldehyde-3-Phosphate Dehydrogenase

Acute lung injury (ALI) is a fatal respiratory disease caused by excessive inflammation. Chelerythrine chloride (CH), an isoquinoline alkaloid, exhibits diverse biological activities. The research focused on assessing CH’s therapeutic effects against LPS-mediated ALI in mice and its underlying mecha...

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Bibliographic Details
Main Authors: Yuting He, Tianyun Fan, Ruishen Zhuge, Huiying Li, Guanjun Li, Lirun Zhou, Liting Xu, Xiaojiang Hao, Wei Gu, Jigang Wang
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
chelerythrine chloride
<i>Chelidonium majus</i> L.
acute lung injury
glycolysis
glyceraldehyde-3-phosphate dehydrogenase
Online Access:https://www.mdpi.com/1420-3049/30/12/2572
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