Diastereoselective Synthesis and Biological Evaluation of Spiro[chromane-2,4′-pyrimidin]-2′(3′<i>H</i>)-ones as Novel Antimicrobial and Antioxidant Agents

Diastereoselective Synthesis and Biological Evaluation of Spiro[chromane-2,4′-pyrimidin]-2′(3′<i>H</i>)-ones as Novel Antimicrobial and Antioxidant Agents

This study reports an improved diastereoselective synthesis of substituted spiro[chromane-2,4′-pyrimidin]-2′(3′<i>H</i>)-ones via the acid-catalyzed condensation of 6-styryl-4-aryldihydropyrimidin-2-ones with resorcinol, 2-methylresorcinol, and pyrogallol. The optimized method allows for...

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Bibliographic Details
Main Authors: Alena S. Karandeeva, Natalia A. Bogdanova, Mariya V. Kabanova, Sergey I. Filimonov, Zhanna V. Chirkova, Anna A. Romanycheva, Valeria A. Panova, Anton A. Shetnev, Nurila A. Togyzbayeva, Saken A. Kanzhar, Nurbol O. Appazov, Kyrill Yu. Suponitsky
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
heterocycles
spirochromane-pyrimidines
resorcinol
2-methylresorcinol
pyrogallol
acid catalysis
Online Access:https://www.mdpi.com/1420-3049/30/14/2954
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