A Novel Method for Preparing Uniform Micro-Sized Dry Powder Formulations, Including Aggregation-Controlled VHH

A Novel Method for Preparing Uniform Micro-Sized Dry Powder Formulations, Including Aggregation-Controlled VHH

Background: The preparation of antibodies in powder form without changing their physicochemical properties may enable their use in new drug delivery system therapies or non-refrigerated storage. The variable domain of heavy-chain antibodies (VHHs) is more suited for this purpose than that of convent...

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Bibliographic Details
Main Authors: Tatsuru Moritani, Hidekazu Masaki, Ryo Yonehara, Takeru Suzuki, Hidenao Arai, Masayuki Tsuchiya, Naoto Nemoto
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antibodies
Subjects:
nanobody
single-domain antibody
fine droplet drying process
microparticle
inhalable powder
intratracheal administration
Online Access:https://www.mdpi.com/2073-4468/14/2/29
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https://www.mdpi.com/2073-4468/14/2/29

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