Differential DNA methylation patterns in whole blood from ACPA-positive patients with DMARD-naïve rheumatoid arthritis at clinical disease onset

Differential DNA methylation patterns in whole blood from ACPA-positive patients with DMARD-naïve rheumatoid arthritis at clinical disease onset

ObjectiveEpigenetic DNA imprints are increasingly being recognized as co-drivers of disease in complex conditions. In this exploratory and hypothesis-generating epigenome-wide association study (EWAS), we investigated differential methylation patterns in peripheral blood leucocytes from patients wit...

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Bibliographic Details
Main Authors: Anders Jørgen Svendsen, Jonas Mengel-From, Peter Junker, Christine Dalgård, George Davey Smith, Caroline L. Relton, Hannah R. Elliott, Kirsten Kyvik, Hanne Lindegaard, Anne Friesgaard Christensen, Qihua Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
anti-CCP antibodies
epigenetics
DNA-methylation
incidence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1488161/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1488161/full

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