Enhancing HepG2 cell apoptosis with a combined nanoparticle delivery of miR-128–3p agomir and Oroxin B: A novel drug delivery approach based on PI3K-AKT and VEGF pathway crosstalk

Enhancing HepG2 cell apoptosis with a combined nanoparticle delivery of miR-128–3p agomir and Oroxin B: A novel drug delivery approach based on PI3K-AKT and VEGF pathway crosstalk

Hepatocellular carcinoma (HCC) shows the highest morbidity among liver cancers which is characterized by genetic mutations in hepatocytes, leading to uncontrolled cell growth and proliferation. Current treatment include surgery, chemotherapy and immunotherapy; however, chemotherapeutics, which focus...

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Bibliographic Details
Main Authors: Hechen Wang, Xudan Shen, Jiatong Liu, Xinlan Zhu, Su Zeng, Sheng Cai
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
NA-miR-128–3p
Nucleic acid drug
Hepatocellular carcinoma
Oroxin B
Combinative administration
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087624000266
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