FAS APOPTOTIC GENE POLYMORPHISM (-670A/G) IS ASSOCIATED WITH CLINICAL PHENOTYPES OF SYSTEMIC SCLEROSIS IN A RUSSIAN POPULATION: A PILOT STUDY

FAS APOPTOTIC GENE POLYMORPHISM (-670A/G) IS ASSOCIATED WITH CLINICAL PHENOTYPES OF SYSTEMIC SCLEROSIS IN A RUSSIAN POPULATION: A PILOT STUDY

The FAS antigen (Apo-1/CD95) is a key molecule of apoptosis in most cell types, including activated immune cells and fibroblasts. The FAS gene promoter region contains a single-nucleotide polymorphism (-670A/G) associated with a substitution of the nucleotide arginine for guanine, which is associate...

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Bibliographic Details
Main Authors: M. Yu. Krylov, L. P. Ananyeva, O. A. Koneva, M. N. Starovoitova, E. Yu. Samarkina, O. V. Desinova, O. B. Ovsyannikova, E. N. Aleksandrova, A. A. Novikov, I. A. Guseva
Format: Article
Language:Russian
Published: IMA PRESS LLC 2017-03-01
Series:Научно-практическая ревматология
Subjects:
fas gene
polymorphism
systemic sclerosis
clinical and serological phenotypes
Online Access:https://rsp.mediar-press.net/rsp/article/view/2336
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https://rsp.mediar-press.net/rsp/article/view/2336

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