USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2

USP10 protects against pressure overload-induced mitochondrial morphofunctional defects and pathological cardiac hypertrophy through stabilizing cytoplasmic Mfn2

Increasing evidence has implicated the important role of mitochondrial morphofunctional defects in pathological myocardial hypertrophy and heart failure. Deubiquitinating enzymes (DUBs) are involved in protein stability maintenance and regulate multiple cellular processes, while it remains largely u...

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Bibliographic Details
Main Authors: Runjing Li, Feng Gao, Yunan Chen, Jiamin Zhao, Rui Shi, Man Li, Zhenzi Zuo, Pan Chang, Dema De, Lin Chen, Feng Fu, Mingge Ding
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Pathological cardiac hypertrophy
Heart failure
USP10
Mfn2
Mitochondrial morphofunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002587
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