Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs

Lack of an atypical PDR transporter generates an immunogenic Cryptococcus neoformans strain that drives a dysregulated and lethal immune response in murine lungs

ABSTRACT Cryptococcus neoformans is an opportunistic fungal pathogen responsible for >150,000 deaths every year, with a mortality rate as high as 81%. This high medical burden is due, in part, to an incomplete understanding of its pathogenesis. In a previous study, we identified a cryptococcal at...

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Bibliographic Details
Main Authors: Christopher J. Winski, Peter V. Stuckey, Armando M. Marrufo, Georgina Agyei, Robbi L. Ross, Tamanna Urmi, Sarah Chapman, Felipe H. Santiago-Tirado
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
Cryptococcus neoformans
fungal pathogen
PDR transporter
fungal immunity
Online Access:https://journals.asm.org/doi/10.1128/mbio.01321-25
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https://journals.asm.org/doi/10.1128/mbio.01321-25

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