DNA-demethylation by DAC induces MAGE expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets

Cancer testis antigens (CTAs) can be expressed in tumors, whereas expression is silenced in normal tissue except for the immune-privileged testis. This quasi-tumor-restricted expression makes CTAs attractive targets for T cell receptor (TCR) gene therapy. However, CTA-specific TCR gene therapy is on...

Full description

Saved in:

Bibliographic Details
Main Authors:	Marije A.J. de Rooij, Miranda H. Meeuwsen, Anne K. Wouters, Dennis F.G. Remst, Renate S. Hagedoorn, Dirk M. van der Steen, Els M.E. Verdegaal, Tassilo L.A. Wachsmann, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Series:	Molecular Therapy: Oncology
Subjects:	MT: Regular Issue CD8+ T cell TCR DAC MAGE DNA-demethylation
Online Access:	http://www.sciencedirect.com/science/article/pii/S2950329925000876
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!

DNA-demethylation by DAC induces MAGE expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets

Similar Items