Chondroitin sulfate regulates proliferation of Drosophila intestinal stem cells.

The basement membrane (BM) plays critical roles in stem cell maintenance and activity control. Here we show that chondroitin sulfate (CS), a major component of the Drosophila midgut BM, is required for proper control of intestinal stem cells (ISCs). Loss of Chsy, a critical CS biosynthetic gene, res...

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Bibliographic Details
Main Authors: Collin Knudsen, Ayano Moriya, Eriko Nakato, Rishi Gulati, Takuya Akiyama, Hiroshi Nakato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011686
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