Systemic regulatory factors of angiogenesis in multiple uterine myoma
Uterine leiomyomas (UL) are benign uterine tumors. Hypertrophic increase in muscle mass in LM is accompanied by development of vascular networks, which are regulated by the balance of pro-angiogenic factors, e.g., VEGF-A. Moreover, a number of inflammatory molecules exert pro-angiogenic effects, esp...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2025-01-01
|
| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/2978 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839571286455484416 |
|---|---|
| author | V. I. Konenkov A. V. Shevchenko V. F. Prokofiev E. G. Koroleva Yu. S. Timofeeva S. V. Aidagulova I. O. Marinkin |
| author_facet | V. I. Konenkov A. V. Shevchenko V. F. Prokofiev E. G. Koroleva Yu. S. Timofeeva S. V. Aidagulova I. O. Marinkin |
| author_sort | V. I. Konenkov |
| collection | DOAJ |
| description | Uterine leiomyomas (UL) are benign uterine tumors. Hypertrophic increase in muscle mass in LM is accompanied by development of vascular networks, which are regulated by the balance of pro-angiogenic factors, e.g., VEGF-A. Moreover, a number of inflammatory molecules exert pro-angiogenic effects, especially, IL-1β, IL-8, etc. The spectrum of their activity may overlap, being regulated by other cytokines. The aim of our work was to assess serum concentrations of cytokines actively involved in vascular network growth in the patients with multiple uterine fibroids, as compared with data obtained in conditionally healthy women. The survey included 178 females: 89 women (23-60 years old) with uterine fibroids, and 89 conditionally healthy age-matched women (22-61 years old). The levels of TNFα, IL-1β, IL-4, IL-6, IL-8, IL-10 and VEGF-A were detected by ELISA technique (Vector-Best, Russia). Statistical analysis was carried out using the IBM SPSS Statistics 23 (USA). Serum levels of IL-6, TNF and IL-8, were higher among patients compared with healthy women. The dependence of VEGF level on the number of myoma nodes has been established: VEGF serum level was higher in patients with multiple tumor nodes. In healthy women, an increase in TNFα level showed direct correlation with higher serum level of IL-6. Correlation with VEGF level was weakly negative. In leiomyoma, these relationships persist for IL-6, IL-8, VEGF levels. The obtained data are of practical importance not only as potential prognostic criteria for development of the uterine myoma at preclinical stage, but also as additional laboratory indexes for differential diagnostics, in particular when discerning uterine leiomyoma, the most common benign myomatous tumor of uterus, from malignant uterine leiomyosarcomas. |
| format | Article |
| id | doaj-art-88bcf5b0f5d14b83a7a7d0cda2c83b26 |
| institution | Matheson Library |
| issn | 1563-0625 2313-741X |
| language | Russian |
| publishDate | 2025-01-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj-art-88bcf5b0f5d14b83a7a7d0cda2c83b262025-08-04T14:30:44ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2025-01-01271576810.15789/1563-0625-SFR-29781953Systemic regulatory factors of angiogenesis in multiple uterine myomaV. I. Konenkov0A. V. Shevchenko1V. F. Prokofiev2E. G. Koroleva3Yu. S. Timofeeva4S. V. Aidagulova5I. O. Marinkin6Research Institute of Clinical and Experimental Lymphology, Institute Cytology and Genetics, Siberian Branch, Russian Academy of SciencesResearch Institute of Clinical and Experimental Lymphology, Institute Cytology and Genetics, Siberian Branch, Russian Academy of SciencesResearch Institute of Clinical and Experimental Lymphology, Institute Cytology and Genetics, Siberian Branch, Russian Academy of SciencesAvicenna Medical CenterAvicenna Medical Center; Novosibirsk State Medical UniversityNovosibirsk State Medical UniversityNovosibirsk State Medical UniversityUterine leiomyomas (UL) are benign uterine tumors. Hypertrophic increase in muscle mass in LM is accompanied by development of vascular networks, which are regulated by the balance of pro-angiogenic factors, e.g., VEGF-A. Moreover, a number of inflammatory molecules exert pro-angiogenic effects, especially, IL-1β, IL-8, etc. The spectrum of their activity may overlap, being regulated by other cytokines. The aim of our work was to assess serum concentrations of cytokines actively involved in vascular network growth in the patients with multiple uterine fibroids, as compared with data obtained in conditionally healthy women. The survey included 178 females: 89 women (23-60 years old) with uterine fibroids, and 89 conditionally healthy age-matched women (22-61 years old). The levels of TNFα, IL-1β, IL-4, IL-6, IL-8, IL-10 and VEGF-A were detected by ELISA technique (Vector-Best, Russia). Statistical analysis was carried out using the IBM SPSS Statistics 23 (USA). Serum levels of IL-6, TNF and IL-8, were higher among patients compared with healthy women. The dependence of VEGF level on the number of myoma nodes has been established: VEGF serum level was higher in patients with multiple tumor nodes. In healthy women, an increase in TNFα level showed direct correlation with higher serum level of IL-6. Correlation with VEGF level was weakly negative. In leiomyoma, these relationships persist for IL-6, IL-8, VEGF levels. The obtained data are of practical importance not only as potential prognostic criteria for development of the uterine myoma at preclinical stage, but also as additional laboratory indexes for differential diagnostics, in particular when discerning uterine leiomyoma, the most common benign myomatous tumor of uterus, from malignant uterine leiomyosarcomas.https://www.mimmun.ru/mimmun/article/view/2978uterine fibroidsenzyme-linked immunosorbent assaytnf-ail-1il-4l-6il-8il-10vegf |
| spellingShingle | V. I. Konenkov A. V. Shevchenko V. F. Prokofiev E. G. Koroleva Yu. S. Timofeeva S. V. Aidagulova I. O. Marinkin Systemic regulatory factors of angiogenesis in multiple uterine myoma Медицинская иммунология uterine fibroids enzyme-linked immunosorbent assay tnf-a il-1 il-4 l-6 il-8 il-10 vegf |
| title | Systemic regulatory factors of angiogenesis in multiple uterine myoma |
| title_full | Systemic regulatory factors of angiogenesis in multiple uterine myoma |
| title_fullStr | Systemic regulatory factors of angiogenesis in multiple uterine myoma |
| title_full_unstemmed | Systemic regulatory factors of angiogenesis in multiple uterine myoma |
| title_short | Systemic regulatory factors of angiogenesis in multiple uterine myoma |
| title_sort | systemic regulatory factors of angiogenesis in multiple uterine myoma |
| topic | uterine fibroids enzyme-linked immunosorbent assay tnf-a il-1 il-4 l-6 il-8 il-10 vegf |
| url | https://www.mimmun.ru/mimmun/article/view/2978 |
| work_keys_str_mv | AT vikonenkov systemicregulatoryfactorsofangiogenesisinmultipleuterinemyoma AT avshevchenko systemicregulatoryfactorsofangiogenesisinmultipleuterinemyoma AT vfprokofiev systemicregulatoryfactorsofangiogenesisinmultipleuterinemyoma AT egkoroleva systemicregulatoryfactorsofangiogenesisinmultipleuterinemyoma AT yustimofeeva systemicregulatoryfactorsofangiogenesisinmultipleuterinemyoma AT svaidagulova systemicregulatoryfactorsofangiogenesisinmultipleuterinemyoma AT iomarinkin systemicregulatoryfactorsofangiogenesisinmultipleuterinemyoma |