Toxicity Assessment and Antifungal Potential of Copper(II) and Silver(I) Complexes with 1,10-Phenanthroline-5,6-dione Against Drug-Resistant Clinical Isolates of <i>Cryptococcus gattii</i> and <i>Cryptococcus neoformans</i>

Toxicity Assessment and Antifungal Potential of Copper(II) and Silver(I) Complexes with 1,10-Phenanthroline-5,6-dione Against Drug-Resistant Clinical Isolates of <i>Cryptococcus gattii</i> and <i>Cryptococcus neoformans</i>

The World Health Organization included <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i> in its priority fungal pathogen list due to their high mortality rates and frequent treatment failures. These facts have driven research toward the discovery of new compounds...

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Main Authors: Lucas Giovanini, Ana Lucia Casemiro, Larissa S. Corrêa, Matheus Mendes, Thaís P. Mello, Lucieri O. P. Souza, Luis Gabriel Wagner, Christiane Fernandes, Matheus M. Pereira, Lais C. S. V. de Souza, Andrea R. S. Baptista, Josué de Moraes, Malachy McCann, Marta H. Branquinha, André L. S. Santos
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Journal of Fungi
Subjects:
coordination compounds
phendione
<i>Cryptococcus</i>
<i>Galleria mellonella</i>
antifungal
toxicity
Online Access:https://www.mdpi.com/2309-608X/11/6/436
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