Development and Characterization of a New Oral Antileishmanial Bis(pyridine-2-Carboxamidine) Drug Through Innovative Dissolution Testing in Biorelevant Media Combined with Pharmacokinetic Studies

Development and Characterization of a New Oral Antileishmanial Bis(pyridine-2-Carboxamidine) Drug Through Innovative Dissolution Testing in Biorelevant Media Combined with Pharmacokinetic Studies

<b>Background/Objectives</b>: Currently there are very few effective oral antileishmanial treatments. In this study we evaluated a new bis(pyridine-2-carboxamidine) antileishmanial drug (JNII40_base) and its hydrochloride salt (JNII40_HCl). <b>Methods</b>: The characterizatio...

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Main Authors: Almudena Laguna, Borja Martínez-Alonso, Víctor Guarnizo-Herrero, J. Jonathan Nué-Martinez, Christophe Dardonville, Santiago Torrado-Santiago, Carlos Torrado-Salmerón
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
antileishmanial drug
surfactant
characterization
biorelevant media
pharmacokinetic study
Online Access:https://www.mdpi.com/1999-4923/17/7/838
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https://www.mdpi.com/1999-4923/17/7/838

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