The knockout of Moesin leads to excess microglia-mediated synaptic pruning and impairs social novelty in a mouse model

The knockout of Moesin leads to excess microglia-mediated synaptic pruning and impairs social novelty in a mouse model

Summary: Genome-wide association studies (GWASs) have implicated a noncoding antisense RNA designated as MSNP1AS (Moesin pseudogene 1, antisense) in susceptibility to autism spectrum disorders (ASDs). MSNP1AS binds to and downregulates the Moesin (Msn) transcript and is highly overexpressed in the p...

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Main Authors: Wanjing Lai, Junlin Chen, Hongyao Zhu, Yunbo Jiang, Yimei Niu, Qingpei Chen, Zhihua Luo, Yu Hu, Li Fang, Yaxuan Wang, Youqiang Song, Charlly Kao, Jubao Duan, Kwok-Fai So, Hakon Hakonarson, Li Zhang, Kai Wang, Lingling Shi
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007831
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http://www.sciencedirect.com/science/article/pii/S2211124725007831

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