Autophagy-induced NR2F1 activation promotes the apoptosis of lens epithelial cells and facilitates cataract-associated fibrosis through targeting STAT3

Autophagy-induced NR2F1 activation promotes the apoptosis of lens epithelial cells and facilitates cataract-associated fibrosis through targeting STAT3

Cataracts, a widely prevalent ocular pathology, engender visual impairment and emerge as a primary etiological factor contributing to ocular blindness. Substantial evidence substantiates that epithelial–mesenchymal transition stands prominently among the pivotal causative factors associated with thi...

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Main Authors: Hangjia Zuo, Xianyang Liu, Bingjing Lv, Ning Gao, Miaomiao Du, Xiang Gao, Yongguo Xiang, Rongxi Huang, Meiting Lin, Yakun Wang, Yonglin Chen, Hong Cheng, Tong Zhang, Shijie Zheng, Wenjuan Wan, Ke Hu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-09-01
Series:Genes and Diseases
Subjects:
Apoptosis
Autophagy
Cataracts
Epithelial-mesenchymal transition
JAK1/STAT3 pathway
NR2F1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304225000388
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