‘Druggability’ of the Per–Arnt–Sim (PAS) domains of human PAS domain kinase, a therapeutic target for metabolic and liver disorders

‘Druggability’ of the Per–Arnt–Sim (PAS) domains of human PAS domain kinase, a therapeutic target for metabolic and liver disorders

Per–Arnt–Sim (PAS) domain kinase (PASK) is a conserved metabolic sensor that modulates the activation of critical proteins involved in liver metabolism and fitness. However, despite its key role in mastering the metabolic regulation, the molecular mechanism of PASK’s activity is ongoing research, an...

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Bibliographic Details
Main Authors: Shangze Xu, Lanyu Fan, Piotr Zaborniak, Ruidi Zhu, Haoyuan Ji, Kate S. Harris, João V. de Souza, Agnieszka K. Bronowska
Format: Article
Language:English
Published: Cambridge University Press 2025-01-01
Series:QRB Discovery
Subjects:
Computational modelling
target validation
drug site mapping
Online Access:https://www.cambridge.org/core/product/identifier/S2633289224000012/type/journal_article
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https://www.cambridge.org/core/product/identifier/S2633289224000012/type/journal_article

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