The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice

The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice

Over the last few decades, scientists' attention has shifted from neuronal to non-neuronal cells to explain the mechanisms at the basis of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). ALS is a multifactorial and multicellular disease in which microglia have a cent...

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Main Authors: Matilde Balbi, Carola Torazza, Tiziana Altosole, Silvia Ravera, Emanuele Farinini, Sara Tessitore, Francesca Bacchetti, Francesca Rosso, Ilaria Musante, Silvana Alfei, Maria Cerminara, Aldamaria Puliti, Gilberto Filaci, Daniela Fenoglio, Riccardo Leardi, Ernesto Fedele, Giambattista Bonanno, Marco Milanese, Tiziana Bonifacino
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Microglia
Astrocytes
Metabotropic glutamate receptor 5
SOD1G93A
Negative allosteric modulator
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002335
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