Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Functionalized Biomimetic Nanoparticles Targeting the IL‐10/IL‐10Rα/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis

Abstract Osteoarthritis (OA) is a low‐grade inflammatory disease that is highly associated with severe hyperplasia of the synovial membrane and the degeneration of cartilage. Interleukin‐10 (IL‐10), has been extensively studied, while its receptor, IL‐10Rα, has not been widely mentioned in the conte...

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Bibliographic Details
Main Authors: Wenwei Li, Yang Liu, Ming Wei, Zhichao Yang, Zhaoyu Li, Zezhong Guo, Liang Yan, Yang Lu, Hao Tang, Bofeng Li, Wei Huang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
ferroptosis
glycolysis
HIF‐1α
IL‐10Rα
MOF
osteoarthritis
Online Access:https://doi.org/10.1002/advs.202504768
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https://doi.org/10.1002/advs.202504768

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