The Cholesterol Biosynthesis Pathway Plays an Important Role in Chemotherapeutic Drug Response and Metastasis in High-Grade Osteosarcoma

The Cholesterol Biosynthesis Pathway Plays an Important Role in Chemotherapeutic Drug Response and Metastasis in High-Grade Osteosarcoma

High-grade osteosarcoma (HGOS) is the most common primary malignant bone tumor in children and adolescents. Poor response to chemotherapy is linked to worse prognosis and increased risk of recurrence and metastasis. However, current assessment methods, such as tumor necrosis evaluation, are time-con...

Full description

Saved in:
Bibliographic Details
Main Authors: Amonnat Sukhamwang, Dumnoensun Pruksakorn, Pornngarm Dejkriengkraikul, Apiwat Sangphukieo, Sivamoke Dissook, Supachai Yodkeeree
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
osteosarcoma
transcriptomics
RNA-seq
cholesterol biosynthesis
drug resistance
Online Access:https://www.mdpi.com/2073-4409/14/13/993
Tags: Add Tag
No Tags, Be the first to tag this record!
Login for hold and recall information

Internet

https://www.mdpi.com/2073-4409/14/13/993

Similar Items