Cryogenic mouse tissue homogenization as an alternative to fresh-frozen biopsy use for genomics, transcriptomics, proteomics and metabolomics

Abstract The classical approach of using adjacent pieces of fresh-frozen tissue for various omics analysis from the same sample possesses a risk of biological mismatch between arising from intrinsic tissue heterogeneity. We propose an alternative approach of tissue cryogenic pulverization and lyophi...

Full description

Saved in:
Bibliographic Details
Main Authors: Laimdota Zizmare, Ute Hofmann, Mohamed Ali Jarboui, Franziska Klose, Sabine Fraschka, Jakob Matthes, Marcel Krüger, Elke Schaeffeler, Matthias Schwab, Marius Ueffing, Bernd J. Pichler, Karsten Boldt, Nicolas Casadei, Christoph Trautwein
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-06438-3
Tags: Add Tag
No Tags, Be the first to tag this record!