Type I-E* CRISPR-Cas of Klebsiella pneumoniae upregulates bacterial virulence by targeting endogenous histidine utilization system

Type I-E* CRISPR-Cas of Klebsiella pneumoniae upregulates bacterial virulence by targeting endogenous histidine utilization system

ABSTRACT Klebsiella pneumoniae is a globally recognized microbial pathogen with significant clinical impact. The bacterium harbors the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems, which provide adaptive immunity against invading foreign nucleic acids. Recent studie...

Full description

Saved in:
Bibliographic Details
Main Authors: Jieying Li, Yuxiao Liu, Jingsi Jiang, Fang Chen, Nan Zhang, Xun Kang, Lin Liu, Yingjuan Wang, Qianfeng Xia, Chuanlong Zhu, Dai Kuang
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mSphere
Subjects:
CRISPR-Cas system
Klebsiella pneumoniae
virulence
self-targeting regulation
histidine utilization
Online Access:https://journals.asm.org/doi/10.1128/msphere.00215-25
Tags: Add Tag
No Tags, Be the first to tag this record!
Login for hold and recall information

Internet

https://journals.asm.org/doi/10.1128/msphere.00215-25

Similar Items