Pharmacokinetics and brain tissue distribution of Gastrodia elata extract in normal and cerebral ischemic rats: a comparative study

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Pharmacokinetics and brain tissue distribution of Gastrodia elata extract in normal and cerebral ischemic rats: a comparative study

ObjectiveThis study systematically investigated the pharmacokinetic characteristics, cerebral distribution, and metabolic transformation of Gastrodia elata components in both healthy and cerebral ischemia rat models.MethodsChemical profiling of Gastrodia elata was conducted using UPLC-Q-TOF-MS. Base...

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Bibliographic Details
Main Authors:	Ji Shao, Qi Xu, Yunyun Luo, Ting Dong, Xue Han, Bilian Chen, Huazhong Ying, Cuifen Fang, Qiaojuan Shi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Pharmacology
Subjects:	Gastrodia elata cerebral ischemia pharmacokinetics brain tissue distribution xenobiotic metabolite identification
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1624576/full
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