Casticin activates Rheb GTPase by binding to residue Trp141 and induces tumor senescence
Senescence is a state of irreversible growth arrest that can be induced in colorectal cancer (CRC). Developing drugs that can induce senescent CRC cells without promoting stemness can significantly improve treatment outcomes. Our study reveals a unique mechanism by which casticin (CAS) induces senes...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
Elsevier
2025-08-01
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| Schriftenreihe: | Pharmacological Research |
| Schlagworte: | |
| Online-Zugang: | http://www.sciencedirect.com/science/article/pii/S1043661825002804 |
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