GPR39 agonist TC-G 1008 promotes osteoblast differentiation and mineralization in MC3T3-E1 cells

GPR39 agonist TC-G 1008 promotes osteoblast differentiation and mineralization in MC3T3-E1 cells

Osteoporosis-related bone fracture and falls have a severe impact on patients’ daily lives. Osteoblasts are bone-building cells that play a vital role in bone formation and remodeling. Imbalanced osteoblast differentiation could lead to osteoporosis. GPR39 is an orphan G protein-coupled receptor tha...

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Bibliographic Details
Main Authors: Xingyu Chai, Wencan Zhang, Bingying Chang, Xianli Feng, Jiang Song, Le Li, Chenxiao Yu, Junyong Zhao, Haipeng Si
Format: Article
Language:English
Published: Taylor & Francis Group 2019-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
GPR39
MC3T3-E1
osteoblast differentiation
TC-G 1008
Runx-2
AMPK
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2019.1649270
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https://www.tandfonline.com/doi/10.1080/21691401.2019.1649270

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