Interneuron transcriptomics reveals pathologic markers of Alzheimer's disease progression

Alzheimer's disease (AD) exhibits imbalance between neuronal excitation and inhibition, likely secondary to interneuron dysfunction. To reveal underlying mediators, we spatially profiled the transcriptome of neuronal subtypes in 5XFAD versus control mice at early- and late-stage disease. Pooled...

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Príomhchruthaitheoirí: Kevin S. Chen, Mohamed H. Noureldein, Diana M. Rigan, John M. Hayes, Kyle J. Loi, Junguk Hur, Masha G. Savelieff, Eva L. Feldman
Formáid: Alt
Teanga:Béarla
Foilsithe / Cruthaithe: Elsevier 2025-09-01
Sraith:Neurobiology of Disease
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Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S0969996125002281
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