NK‐Cell‐Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy‐Induced Senescent Osteosarcoma Cells

NK‐Cell‐Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy‐Induced Senescent Osteosarcoma Cells

ABSTRACT Osteosarcoma (OS) is a type of bone tumour characterized by high risk of metastatic progression and recurrence after therapy. Traditional tumour treatment methods such as radiotherapy and chemotherapy can lead to the accumulation of senescent cells in tumours. Treatment‐induced senescence (...

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Bibliographic Details
Main Authors: Xianlin Yue, Jie Cui, Shifeng Ren, Yajun Zhang, Ying Li, Hongjuan Cui, Johnny Huard, Paul D. Robbins, Xiaodong Mu
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Extracellular Vesicles
Subjects:
cellular senescence
extracellular vesicles
natural killer cells
osteosarcoma
senolytic therapy
Online Access:https://doi.org/10.1002/jev2.70123
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https://doi.org/10.1002/jev2.70123

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