From Antiretroviral to Antibacterial: Deep-Learning-Accelerated Repurposing and In Vitro Validation of Efavirenz Against Gram-Positive Bacteria

From Antiretroviral to Antibacterial: Deep-Learning-Accelerated Repurposing and In Vitro Validation of Efavirenz Against Gram-Positive Bacteria

The repurposing potential of Efavirenz (EFV), a clinically established non-nucleoside reverse transcriptase inhibitor, was comprehensively evaluated for its in vitro antibacterial effect either alone or in combination with other antibacterial agents on several Gram-positive clinical strains showing...

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Bibliographic Details
Main Authors: Ezzeldin Saleh, Omar A. Soliman, Nancy Attia, Nouran Rafaat, Daniel Baecker, Mohamed Teleb, Abeer Ghazal, Ahmed Noby Amer
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
antibacterial activity
Efavirenz
drug repurposing
in silico binding study
Online Access:https://www.mdpi.com/1420-3049/30/14/2925
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