Hypoxia impedes differentiation of cranial neural crest cells into derivatives relevant for craniofacial development

Orofacial clefts are the second-most prevalent congenital malformation. Risk factors are multifactorial and include genetic components, but also environmental factors. One environmental factor is hypoxia during pregnancy, caused for instance by tobacco smoking, medication or living at high altitudes...

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Bibliographic Details
Main Authors: Theresa Schmid, Gabriele Rodrian, Elke Bachmann, Alexander Kohler, Michael Wegner, Lina Gölz, Matthias Weider
Format: Article
Language:English
Published: The Royal Society 2025-07-01
Series:Open Biology
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Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.250129
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