Deletion of PPARα in mouse brown adipocytes increases their De Novo Lipogenesis

Deletion of PPARα in mouse brown adipocytes increases their De Novo Lipogenesis

Objective: Peroxisome Proliferator-Activated Receptors (PPARs) are nuclear receptors involved in the control of lipid metabolism. The PPARα isoform is highly expressed in brown adipose tissue (BAT). However, its precise role in BAT remains unclear. Here, we aimed to investigate the role of PPARα in...

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Bibliographic Details
Main Authors: Pierre-Louis Batrow, Sylvie Caspar-Bauguil, Nathalie Rochet, Nadine Gautier, Anne-Sophie Rousseau, Marielle Maret, Samah Rekima, Etienne Mouisel, Emmanuel Van Obberghen, Christian H. Roux, Hervé Guillou, Catherine Postic, Christian Wolfrum, Dominique Langin, Ez-Zoubir Amri, Isabelle Mothe-Satney
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Molecular Metabolism
Subjects:
Peroxisome proliferator-activated receptor alpha
Brown adipose tissue
Inducible UCP1-CRE
High fat diet-induced obesity
β3-adrenergic stimulation
Lipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000912
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