Chain length-dependent mitochondrial toxicity of perfluoroalkyl carboxylic acids: insights from Mito Tox Index evaluation

Chain length-dependent mitochondrial toxicity of perfluoroalkyl carboxylic acids: insights from Mito Tox Index evaluation

IntroductionPer- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that accumulate in living organisms, posing significant human health risks. The toxicity mechanisms of PFAS include mitochondrial dysfunction and bioenergetic failure.MethodsThis study evaluates the stru...

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Bibliographic Details
Main Authors: Yoonseok Kam, Lisa Winer, Natalia Romero
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Toxicology
Subjects:
PFAS (per- and polyfluoroalkyl substances)
mitochondrial dysfunction
cell metabolism and bioenergetics
in vitro toxicity assay
real time cell analysis
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1582891/full
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https://www.frontiersin.org/articles/10.3389/ftox.2025.1582891/full

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