Synthesis of 1-(2-Hydroxy-5-methylphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as a Promising Scaffold Against Disease-Causing Bacteria Relevant to Public Health

Synthesis of 1-(2-Hydroxy-5-methylphenyl)-5-oxopyrrolidine-3-carboxylic Acid Derivatives as a Promising Scaffold Against Disease-Causing Bacteria Relevant to Public Health

The increasing number of antibiotic-resistant pathogens forces us to accelerate the search for new antimicrobial agents. Based on this, we chose to synthesize a library of 1-(2-hydroxy-5-methylphenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives and evaluate their antibacterial activity against va...

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Bibliographic Details
Main Authors: Karolis Krikštaponis, Jūratė Šiugždaitė, Rita Vaickelionienė, Vytautas Mickevičius, Birutė Grybaitė
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
5-oxopyrrolidine
hydrazone
heterocycles
antibacterial activity
biofilm formation
Online Access:https://www.mdpi.com/1420-3049/30/12/2639
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