AAV2 delivery of the saCas9 gene results in presentation of an HLA-A∗02:01-restricted T cell epitope potent to induce T cell cytotoxicity

AAV2 delivery of the saCas9 gene results in presentation of an HLA-A∗02:01-restricted T cell epitope potent to induce T cell cytotoxicity

In vivo genome editing with CRISPR-Cas9 systems is generating worldwide attention and enthusiasm for the possible treatment of genetic disorders. However, the consequences of potential immunogenicity of the bacterial Cas9 protein and the AAV capsid have been the subject of considerable debate. Here,...

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Bibliographic Details
Main Authors: Susana S. Najera, Annalisa Nicastri, Sojin Bing, Abdul Mohin Sajib, Nicola Ternette, Ronit Mazor
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
CRISPR
gene editing
genome editing
immunogenicity
immunotoxicity
MHC I
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125001019
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http://www.sciencedirect.com/science/article/pii/S2329050125001019

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