Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer
Abstract Fructose, a prevalent hexose, has become a widely used food additive, with its usage rising significantly because of socio-economic advancements and shifts in human dietary habits. Excessive fructose intake has been implicated in obesity, cardiovascular disease, metabolic syndromes, inflamm...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Molecular Biomedicine |
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| Online Access: | https://doi.org/10.1186/s43556-025-00287-2 |
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| author | Zhenhong Li Xinzou Fan Fan Gao Shengguang Pan Xiao Ma Hao Cheng Hiroko Nakatsukasa Wei Zhang Dunfang Zhang |
| author_facet | Zhenhong Li Xinzou Fan Fan Gao Shengguang Pan Xiao Ma Hao Cheng Hiroko Nakatsukasa Wei Zhang Dunfang Zhang |
| author_sort | Zhenhong Li |
| collection | DOAJ |
| description | Abstract Fructose, a prevalent hexose, has become a widely used food additive, with its usage rising significantly because of socio-economic advancements and shifts in human dietary habits. Excessive fructose intake has been implicated in obesity, cardiovascular disease, metabolic syndromes, inflammation, and cancer, among other disorders. This review discusses the absorption, distribution, and metabolism of fructose and the links between fructose metabolism and major metabolic pathways. The role of fructose in metabolic diseases, including metabolic dysfunction-associated fatty liver disease, hyperinsulinemia, and hyperuricemia, is also highlighted. Furthermore, the role of fructose in the development of chronic inflammation, including gut inflammation, liver inflammation, and neuroinflammation, is discussed. Lastly, in the context of cancer development, this review summarizes the dual role of fructose in tumors, both pro- and anti-tumor effects. Future studies on the role of fructose in cancer should focus on the complexity of physiological and pathological conditions, such as the specific tumor microenvironment and metabolic status. Fructose has been shown to induce metabolic reprogramming of multiple immune cells and increase pro-inflammatory immune responses; therefore, inhibiting or promoting its metabolism may regulate immune responses. And targeting fructose metabolism may be a promising approach to treating metabolic diseases, inflammation, and cancer. |
| format | Article |
| id | doaj-art-6af6c037bf5540b49082bc207e1cb7e4 |
| institution | Matheson Library |
| issn | 2662-8651 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Molecular Biomedicine |
| spelling | doaj-art-6af6c037bf5540b49082bc207e1cb7e42025-06-29T11:03:59ZengSpringerMolecular Biomedicine2662-86512025-06-016112910.1186/s43556-025-00287-2Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancerZhenhong Li0Xinzou Fan1Fan Gao2Shengguang Pan3Xiao Ma4Hao Cheng5Hiroko Nakatsukasa6Wei Zhang7Dunfang Zhang8Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan UniversityLaboratory of Microbiology and Immunology, Graduate School of Pharmaceutical Sciences, Chiba UniversityDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan UniversityDepartment of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan UniversityAbstract Fructose, a prevalent hexose, has become a widely used food additive, with its usage rising significantly because of socio-economic advancements and shifts in human dietary habits. Excessive fructose intake has been implicated in obesity, cardiovascular disease, metabolic syndromes, inflammation, and cancer, among other disorders. This review discusses the absorption, distribution, and metabolism of fructose and the links between fructose metabolism and major metabolic pathways. The role of fructose in metabolic diseases, including metabolic dysfunction-associated fatty liver disease, hyperinsulinemia, and hyperuricemia, is also highlighted. Furthermore, the role of fructose in the development of chronic inflammation, including gut inflammation, liver inflammation, and neuroinflammation, is discussed. Lastly, in the context of cancer development, this review summarizes the dual role of fructose in tumors, both pro- and anti-tumor effects. Future studies on the role of fructose in cancer should focus on the complexity of physiological and pathological conditions, such as the specific tumor microenvironment and metabolic status. Fructose has been shown to induce metabolic reprogramming of multiple immune cells and increase pro-inflammatory immune responses; therefore, inhibiting or promoting its metabolism may regulate immune responses. And targeting fructose metabolism may be a promising approach to treating metabolic diseases, inflammation, and cancer.https://doi.org/10.1186/s43556-025-00287-2FructoseFructose metabolismInflammationTumor metabolismGlycolysis |
| spellingShingle | Zhenhong Li Xinzou Fan Fan Gao Shengguang Pan Xiao Ma Hao Cheng Hiroko Nakatsukasa Wei Zhang Dunfang Zhang Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer Molecular Biomedicine Fructose Fructose metabolism Inflammation Tumor metabolism Glycolysis |
| title | Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer |
| title_full | Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer |
| title_fullStr | Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer |
| title_full_unstemmed | Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer |
| title_short | Fructose metabolism and its roles in metabolic diseases, inflammatory diseases, and cancer |
| title_sort | fructose metabolism and its roles in metabolic diseases inflammatory diseases and cancer |
| topic | Fructose Fructose metabolism Inflammation Tumor metabolism Glycolysis |
| url | https://doi.org/10.1186/s43556-025-00287-2 |
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