Prevention of chemotherapy drug-mediated human hair follicle damage: combined use of cooling with antioxidant suppresses oxidative stress and prevents matrix keratinocyte cytotoxicity

BackgroundChemotherapy-induced alopecia (CIA) is a distressing side-effect of cancer treatment. Scalp cooling remains the only available method to mitigate CIA, but its effectiveness varies amongst patients. We previously reported that the cytoprotective effects of cooling are temperature dependent....

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Bibliographic Details
Main Authors: Khalidah Ibraheem, Adrian Smith, Andrew Collett, Nikolaos T. Georgopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1558593/full
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