Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis

Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis

IntroductionMesenchymal stem cells (MSCs) participate in the dynamic remodeling of the extracellular matrix during wound healing, natural bleeding processes or cancer progression. Pericellular proteolysis is a key mechanism mediating the aforementioned processes.AimThis study primarily aimed to defi...

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Bibliographic Details
Main Authors: Ramy Abou Rjeily, Christina Mrad, Fatiha Z. El-Ghazouani, Florence Toti, Audrey Cras, Eduardo Angles-Cano
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Medicine
Subjects:
pericellular proteolysis
urokinase plasminogen activator receptor
plasminogen activation pathway
membrane microvesicles
tranexamic acid
mesenchymal stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1570395/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1570395/full

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