Change in Gasdermin-D gene expression in familial Mediterranean fever compared to healthy children with or without acute infections

Background. Gasdermin-D (GSDMD) is an inflammasome regulator. Pyroptosis and GSDMD-mediated interleukin (IL)-1β secretion abolish in GSDMD-deficient familial Mediterranean fever (FMF) knock-in mice. We aimed to investigate GSDMD gene expression (GSDMD-∆), acute phase reactants (APRs), serum IL-1β,...

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Main Authors: Pınar Özge Avar Aydın, İsmail Yaz, Dilan İnan, Zeynep Birsin Özçakar, Sevil Oskay Halaçlı, Deniz Çağdaş
Format: Article
Language:English
Published: Hacettepe University Institute of Child Health 2025-07-01
Series:The Turkish Journal of Pediatrics
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Online Access:https://turkjpediatr.org/article/view/5389
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