Toxicity of new monophenolic synthetic activator of Keap1/Nrf2/ARE redox-sensitive signaling system <i>in vitro</i> and <i>in vivo</i>

Toxicity of new monophenolic synthetic activator of Keap1/Nrf2/ARE redox-sensitive signaling system <i>in vitro</i> and <i>in vivo</i>

One of the promising areas of modern pharmacology is the development of «indirect antioxidants» capable of activating redox-sensitive signaling systems, primarily the Keap1/Nrf2/ARE system. Among its chemical inductors is the hydrophilic monosubstituted monophenol (3’-tert-butyl-4’-hydroxyphenyl)sod...

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Bibliographic Details
Main Authors: M. V. Khrapova, S. E. Khrapov, A. V. Chechushkov, P. M. Kozhin, L. P. Romakh, A. E. Serykh, S. V. Kholshin, N. V. Kandalintseva, E. B. Menshchikova
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Siberian Branch Publishing House 2022-10-01
Series:Сибирский научный медицинский журнал
Subjects:
acute toxicity, proliferative activity, ld<sub>50</sub>, ic<sub>50</sub>, ts-13, mice, bt-474 line, keap1/nrf2/are signaling system
Online Access:https://sibmed.elpub.ru/jour/article/view/880
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