Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis

Small Extracellular Vesicle (sEV) Uptake from Lung Adenocarcinoma and Squamous Cell Carcinoma Alters T-Cell Cytokine Expression and Modulates Protein Profiles in sEV Biogenesis

Background: Despite advances in immunotherapy, non-small-cell lung carcinoma (NSCLC)’s clinical success is limited, possibly due to substantial immunological alterations in advanced cancer patients. This study examines the immunomodulatory effects of sEVs derived from lung adenocarcinoma (ADC) and s...

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Bibliographic Details
Main Authors: Hafiza Padinharayil, Jinsu Varghese, Pulikkottil Raphael Varghese, Cornelia M. Wilson, Alex George
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Proteomes
Subjects:
lung adenocarcinoma
squamous cell carcinoma
T cells
sEVs
cross-treatment
RNA
Online Access:https://www.mdpi.com/2227-7382/13/2/15
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https://www.mdpi.com/2227-7382/13/2/15

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