Inhibition of USP11 attenuates sepsis-associated acute kidney injury by downregulating TGFBR2/Smad3 signaling

Inhibition of USP11 attenuates sepsis-associated acute kidney injury by downregulating TGFBR2/Smad3 signaling

IntroductionSepsis-associated acute kidney injury (AKI) is a common complication of sepsis, which is a severe inflammatory disease with high mortality. The TGF-β/Smad signaling pathway plays an important role in the progression of sepsis, and targeting the TGF-β receptor II (TGFBR2) has been shown t...

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Bibliographic Details
Main Authors: Lu Wang, Wen Tang, Long Jiang, Daquan Zhang, Zhigao Wang, Rennan Guo, Jingjing Wang, Dong Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
USP11
sepsis
acute kidney injury
TGFBR2
Smad3
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1571593/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2025.1571593/full

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