Body composition and serum fetuin-A levels in patients with rheumatoid arthritis
Background. Rheumatoid cachexia is a pathological condition which appears in patients with rheumatoid arthritis with low fat-free mass and normal or high body mass index. Bone mass loss is one of the components of rheumatoid cachexia. Fetuin-A, a major noncollagen protein of bone tissue, regulates b...
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Russian Academy of Sciences, Siberian Branch Publishing House
2020-11-01
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| Series: | Сибирский научный медицинский журнал |
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| Online Access: | https://sibmed.elpub.ru/jour/article/view/493 |
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| author | E. V. Papichev B. V. Zavodovsky L. E. Sivordova Yu. R. Akhverdyan Yu. V. Polyakova I. A. Zborovskaya |
| author_facet | E. V. Papichev B. V. Zavodovsky L. E. Sivordova Yu. R. Akhverdyan Yu. V. Polyakova I. A. Zborovskaya |
| author_sort | E. V. Papichev |
| collection | DOAJ |
| description | Background. Rheumatoid cachexia is a pathological condition which appears in patients with rheumatoid arthritis with low fat-free mass and normal or high body mass index. Bone mass loss is one of the components of rheumatoid cachexia. Fetuin-A, a major noncollagen protein of bone tissue, regulates bone remodeling. Aim of the study was to investigate the prevalence of rheumatoid cachexia and the association of serum fetuin-A level with body composition components in patients with rheumatoid arthritis. Material and methods. 110 patients (8 male and 102 female) with rheumatoid arthritis were enrolled in our study. Serum fetuin-A level was determined by ELISA. Dual-energy X-ray absorptiometry with Total Body program was performed. The diagnosis of rheumatoid cachexia was based on the next criteria: fat-free mass index less than 10th percentiles with fat mass index above 25th percentiles. Results and discussion. We observed rheumatoid cachexia in 25 patients (22,7 %). According to the literature, such patients have an increased risk of developing metabolic syndrome, arterial hypertension and mortality. Positive significant (p < 0,05) correlations were observed between serum fetuin-A levels and right and left lower limb, trunk, gynoid region, both lower limbs and total body bone mass. No statistically significant relationships with other indicators were identified. Fetuin-A negative dynamic in patients with rheumatoid arthritis may be accompanied by the loss of bone mass, which requires the improvement of therapeutic approach. Conclusions. Almost a quarter of patients with rheumatoid arthritis have rheumatic cachexia. Positive correlation between serum fetuin-A levels and lower limbs, trunk, gynoid region and total body bone mass was observed. |
| format | Article |
| id | doaj-art-62b51aa644844ab0b90bacb113c4f7a5 |
| institution | Matheson Library |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| publishDate | 2020-11-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj-art-62b51aa644844ab0b90bacb113c4f7a52025-07-15T11:26:36ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202020-11-01405929710.15372/SSMJ20200511301Body composition and serum fetuin-A levels in patients with rheumatoid arthritisE. V. Papichev0B. V. Zavodovsky1L. E. Sivordova2Yu. R. Akhverdyan3Yu. V. Polyakova4I. A. Zborovskaya5Research Institute of Clinical and Experimental Rheumatology n.a. A.B. ZborovskyResearch Institute of Clinical and Experimental Rheumatology n.a. A.B. ZborovskyResearch Institute of Clinical and Experimental Rheumatology n.a. A.B. ZborovskyResearch Institute of Clinical and Experimental Rheumatology n.a. A.B. ZborovskyResearch Institute of Clinical and Experimental Rheumatology n.a. A.B. ZborovskyResearch Institute of Clinical and Experimental Rheumatology n.a. A.B. ZborovskyBackground. Rheumatoid cachexia is a pathological condition which appears in patients with rheumatoid arthritis with low fat-free mass and normal or high body mass index. Bone mass loss is one of the components of rheumatoid cachexia. Fetuin-A, a major noncollagen protein of bone tissue, regulates bone remodeling. Aim of the study was to investigate the prevalence of rheumatoid cachexia and the association of serum fetuin-A level with body composition components in patients with rheumatoid arthritis. Material and methods. 110 patients (8 male and 102 female) with rheumatoid arthritis were enrolled in our study. Serum fetuin-A level was determined by ELISA. Dual-energy X-ray absorptiometry with Total Body program was performed. The diagnosis of rheumatoid cachexia was based on the next criteria: fat-free mass index less than 10th percentiles with fat mass index above 25th percentiles. Results and discussion. We observed rheumatoid cachexia in 25 patients (22,7 %). According to the literature, such patients have an increased risk of developing metabolic syndrome, arterial hypertension and mortality. Positive significant (p < 0,05) correlations were observed between serum fetuin-A levels and right and left lower limb, trunk, gynoid region, both lower limbs and total body bone mass. No statistically significant relationships with other indicators were identified. Fetuin-A negative dynamic in patients with rheumatoid arthritis may be accompanied by the loss of bone mass, which requires the improvement of therapeutic approach. Conclusions. Almost a quarter of patients with rheumatoid arthritis have rheumatic cachexia. Positive correlation between serum fetuin-A levels and lower limbs, trunk, gynoid region and total body bone mass was observed.https://sibmed.elpub.ru/jour/article/view/493rheumatoid arthritisrheumatoid cachexiabody compositionfetuin-abone tissuelean tissuefat tissuefat mass indexfat-free mass index |
| spellingShingle | E. V. Papichev B. V. Zavodovsky L. E. Sivordova Yu. R. Akhverdyan Yu. V. Polyakova I. A. Zborovskaya Body composition and serum fetuin-A levels in patients with rheumatoid arthritis Сибирский научный медицинский журнал rheumatoid arthritis rheumatoid cachexia body composition fetuin-a bone tissue lean tissue fat tissue fat mass index fat-free mass index |
| title | Body composition and serum fetuin-A levels in patients with rheumatoid arthritis |
| title_full | Body composition and serum fetuin-A levels in patients with rheumatoid arthritis |
| title_fullStr | Body composition and serum fetuin-A levels in patients with rheumatoid arthritis |
| title_full_unstemmed | Body composition and serum fetuin-A levels in patients with rheumatoid arthritis |
| title_short | Body composition and serum fetuin-A levels in patients with rheumatoid arthritis |
| title_sort | body composition and serum fetuin a levels in patients with rheumatoid arthritis |
| topic | rheumatoid arthritis rheumatoid cachexia body composition fetuin-a bone tissue lean tissue fat tissue fat mass index fat-free mass index |
| url | https://sibmed.elpub.ru/jour/article/view/493 |
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