Low sensitivity of the fourth‐generation antigen/antibody HIV rapid diagnostic test Determine™ HIV Early Detect for detection of acute HIV infection at the point of care in rural Eswatini: a diagnostic accuracy study

Low sensitivity of the fourth‐generation antigen/antibody HIV rapid diagnostic test Determine™ HIV Early Detect for detection of acute HIV infection at the point of care in rural Eswatini: a diagnostic accuracy study

Abstract Introduction The diagnosis of acute HIV infection (AHI) is challenging in routine settings because it cannot be detected by routine third‐generation antibody rapid diagnostic tests (RDTs). The current fourth‐generation antibody/antigen RDT, Determine™ HIV Early Detect, has demonstrated high...

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Main Authors: Iza Ciglenecki, Nombuso Ntshalintshali, Esther Mukooza, Skinner Lekelem, Mpumelelo Mavimbela, Sindisiwe Dlamini, Lenhle Dube, Nomvuyo Mabuza, Melat Haile, Tom Ellman, Antonio Flores, Olivia Keiser, Sindy Matse, Roberto de laTour, Alexandra Calmy, Bernhard Kerschberger
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of the International AIDS Society
Subjects:
acute HIV infection
HIV infection
diagnostic testing
rapid diagnostic test
sub‐Saharan Africa
HIV
Online Access:https://doi.org/10.1002/jia2.26517
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https://doi.org/10.1002/jia2.26517

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