Search of the correlation berween anxiolytic effect of original derivative of pyrrolo [1,2-A] pyrazine TSPO-LIGAND (GML-1) and its concentrations in the rat blood plasma
Resume. Comparison of “concentration-effect” relation for a new potential anxiolytic drug GML-1, being TSPO Ligand was carried out. GML-1 was administered in rats once, intragastricaLLy in the dose 1 mg/kg. Tested drug concentrations in the rat bLood plasma and animaLs behavior in the test of “eLeva...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2018-03-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/60 |
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| Summary: | Resume. Comparison of “concentration-effect” relation for a new potential anxiolytic drug GML-1, being TSPO Ligand was carried out. GML-1 was administered in rats once, intragastricaLLy in the dose 1 mg/kg. Tested drug concentrations in the rat bLood plasma and animaLs behavior in the test of “eLevated pLus maze” were evaLuated. A vaLue of GML-1 anxioLytic effect does not correLate to concentration in the rat bLood pLasma. |
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| ISSN: | 2587-7836 2686-8830 |