Methodology for generating chorioallantoic membrane patient-derived xenograft (CAM-PDX) models of pleural mesothelioma and performing preclinical imaging for the translation of cancer studies and drug screening. [version 1; peer review: 2 approved]

Methodology for generating chorioallantoic membrane patient-derived xenograft (CAM-PDX) models of pleural mesothelioma and performing preclinical imaging for the translation of cancer studies and drug screening. [version 1; peer review: 2 approved]

Background Pleural mesothelioma is a cancer of the lung lining associated with asbestos exposure. Platinum/pemetrexed chemotherapy has been used for many years but provides little benefit and, despite recent immunotherapy advances, prognosis remains poor underpinning the need for development of nove...

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Bibliographic Details
Main Authors: Judy M Coulson, Joseph J Sacco, Michael Shackcloth, Alexander Haragan, Doris M Rassl, Harish Poptani, Anne Herrmann, Liam Shaw, Sarah Barnett, Jan Schulze
Format: Article
Language:English
Published: F1000 Research Ltd 2025-05-01
Series:F1000Research
Subjects:
Chorioallantoic membrane
PDX
pleural mesothelioma
3Rs
preclinical model
PET/CT imaging
eng
Online Access:https://f1000research.com/articles/14-481/v1
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