Novel Benzenesulfonamide Derivatives of 5′-Aminospirotriazolotriazine Exhibit Anti-Inflammatory Activity by Suppressing Pro-Inflammatory Mediators: In Vitro and In Vivo Evaluation Using a Rat Model of Carrageenan-Induced Paw Edema

Novel Benzenesulfonamide Derivatives of 5′-Aminospirotriazolotriazine Exhibit Anti-Inflammatory Activity by Suppressing Pro-Inflammatory Mediators: In Vitro and In Vivo Evaluation Using a Rat Model of Carrageenan-Induced Paw Edema

<b>Background/Objectives</b>: Inflammation is a crucial and complex mechanism that protects the body against infections. In our study, we propose to provide scientific evidence for the anti-inflammatory properties of 1,3,5-triazine derivatives. <b>Methods</b>: Initially, we e...

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Bibliographic Details
Main Authors: Amany M. Hamed, Souhaila S. Enaili, Walaa I. Mohammed, Azza M. A. Abouelella, Zeyad Elsayed Eldeeb Mohana, Dina M. Monir, Safaa S. Soliman, Elsayed Eldeeb Mehana Hamouda, Hytham Mahmoud Abd Elatif, Ahmed M. El-Saghier
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomedicines
Subjects:
1,3,5-triazine derivatives
anti-inflammatory
carrageenan
MTT assay
cox isoenzymes
indomethacin
Online Access:https://www.mdpi.com/2227-9059/13/7/1732
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